Indometh                 package:nls                 R Documentation

Pharmacokinetics of Indomethicin

Description:

     The `Indometh' data frame has 66 rows and 3 columns of data on the
     pharmacokinetics of indomethicin.

Format:

     This data frame contains the following columns:

     Subject an ordered factor with containing the subject codes.  The
          ordering is according to increasing maximum response.

     time a numeric vector of times at which blood samples were drawn
          (hr).

     conc a numeric vector of plasma concentrations of indomethicin
          (mcg/ml).

Details:

     Each of the six subjects were given an intravenous injection of
     indomethicin.

Source:

     Kwan, Breault, Umbenhauer, McMahon and Duggan (1976), ``Kinetics
     of Indomethicin absorption, elimination, and enterohepatic
     circulation in man'', Journal of Pharmacokinetics and
     Biopharmaceutics, 4, 255-280.

     Davidian, M. and Giltinan, D. M. (1995) Nonlinear Models for
     Repeated Measurement Data, Chapman & Hall (section 5.2.4, p. 134)

     Pinheiro, J. C. and Bates, D. M. (2000) Mixed-effects Models in S
     and S-PLUS, Springer.

Examples:

     data(Indometh)
     fm1 <- nls(conc ~ SSbiexp(time, A1, lrc1, A2, lrc2),
                data = Indometh, subset = Subject == 1)
     summary(fm1)

