ID   CO9_FUGRU      STANDARD;      PRT;   586 AA.
AC   P79755;
DT   01-NOV-1997 (REL. 35, CREATED)
DT   01-NOV-1997 (REL. 35, LAST SEQUENCE UPDATE)
DT   01-NOV-1998 (REL. 37, LAST ANNOTATION UPDATE)
DE   COMPLEMENT COMPONENT C9 PRECURSOR.
GN   C9.
OS   FUGU RUBRIPES (JAPANESE PUFFERFISH) (TAKIFUGU RUBRIPES).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; PISCES; GNATHOSTOMATA;
OC   OSTEICHTHYES; ACTINOPTERYGII; TETRAODONTIFORMES.
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 98038993.
RA   YEO G.S.H., ELGAR G., SANDFORD R., BRENNER S.;
RL   GENE 200:203-211(1997).
CC   -!- FUNCTION: C9 IS THE FINAL COMPONENT OF THE COMPLEMENT SYSTEM TO BE
CC       ADDED IN THE ASSEMBLY OF THE MEMBRANE ATTACK COMPLEX. IT IS ABLE
CC       TO ENTER LIPID BILAYERS, FORMING TRANSMEMBRANE CHANNELS (BY
CC       SIMILARITY).
CC   -!- SIMILARITY: TO COMPLEMENT FACTORS C6, C7, C8, AND TO PERFORIN.
CC   -!- SIMILARITY: CONTAINS 2 TYPE-1 TSP REPEATS.
CC   -!- SIMILARITY: CONTAINS 1 EGF-LIKE DOMAIN.
CC   -!- SIMILARITY: CONTAINS 1 LDL-RECEPTOR CLASS A DOMAIN.
CC   --------------------------------------------------------------------------
CC   This SWISS-PROT entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use  by  non-profit  institutions as long  as its content  is  in  no  way
CC   modified and this statement is not removed.  Usage  by  and for commercial
CC   entities requires a license agreement (See http://www.isb-sib.ch/announce/
CC   or send an email to license@isb-sib.ch).
CC   --------------------------------------------------------------------------
DR   EMBL; U87241; G1845349; -.
DR   PROSITE; PS00279; MAC_PERFORIN; 1.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; FALSE_NEG.
DR   PROSITE; PS01209; LDLRA_1; 1.
DR   PROSITE; PS50068; LDLRA_2; 1.
KW   COMPLEMENT PATHWAY; COMPLEMENT ALTERNATE PATHWAY; GLYCOPROTEIN;
KW   PLASMA; MEMBRANE ATTACK COMPLEX; CYTOLYSIS; SIGNAL; EGF-LIKE DOMAIN;
KW   REPEAT.
FT   SIGNAL        1     26       POTENTIAL.
FT   CHAIN        27    586       COMPLEMENT COMPONENT C9.
FT   REPEAT       36     93       TYPE-1 TSP 1.
FT   DOMAIN       94    131       LDL-RECEPTOR CLASS A.
FT   DOMAIN      490    524       EGF-LIKE.
FT   REPEAT      540    586       TYPE-1 TSP 2.
FT   DISULFID     96    108       BY SIMILARITY.
FT   DISULFID    103    121       BY SIMILARITY.
FT   DISULFID    115    129       BY SIMILARITY.
FT   DISULFID    363    389       BY SIMILARITY.
FT   DISULFID    494    510       BY SIMILARITY.
FT   DISULFID    497    512       BY SIMILARITY.
FT   DISULFID    514    523       BY SIMILARITY.
FT   CARBOHYD    246    246       POTENTIAL.
FT   CARBOHYD    274    274       POTENTIAL.
FT   CARBOHYD    354    354       POTENTIAL.
FT   CARBOHYD    545    545       POTENTIAL.
SQ   SEQUENCE   586 AA;  65197 MW;  40CEB614 CRC32;
     MRTEAALQLG FCALCVMLAL LGEGMGRELP DPPAVNCVWS RWAPWSSCDP CTNTRRRSRG
     VEVFGQFAGI ACQGSVGDRE YCITNAKCNL PPPRECSDSE FQCESGSCIK LRLKCNGDYD
     CEDGSDEDCE PLRKTCPPTV LDTNEQGRTA GYGINILGAD PRMNPFNNDF FNGRCDKVRN
     PNTLQLDRLP WNIGVLNYQT LVEETASREI YEDSYSLLRE MLKEMSIKVD AGLSFKFKST
     EPSMSNNSLK LDASLEYEKK TMIKDVSELT NIKNKSFMRV KGRLQLSTYR MRSHQLQVAD
     EFVAHVKSLP LEYEKGIYYA FLEDYGTHYT KNGKSGGEYE LVYVLNQDTI KAKNLTERKI
     QECLKIGIEA EFATTSVQDG KAHAKLNKCD DVTTKSQGDV EGKAVVDNVM TSVKGGSLES
     AVTMRAKLNK EGVMDIATYQ NWARTIASAP ALINSEPEPI YMLIPTDIPG ANSRIANLKQ
     ATADYVAEYN VCKCRPCHNG GTLALLDGKC ICMCSNLFEG LGCQNFKGDK ARVPAARPAV
     TQEGNWSCWS SWSNCQGQKR SRTRYCNTEG VLGAECRGEI RSEEYC
//
ID   E2BB_FUGRU     STANDARD;      PRT;   355 AA.
AC   Q90511;
DT   15-JUL-1998 (REL. 36, CREATED)
DT   15-JUL-1998 (REL. 36, LAST SEQUENCE UPDATE)
DT   01-NOV-1998 (REL. 37, LAST ANNOTATION UPDATE)
DE   TRANSLATION INITIATION FACTOR EIF-2B BETA SUBUNIT (EIF-2B GDP-GTP
DE   EXCHANGE FACTOR) (S20I15).
GN   EIF2BB.
OS   FUGU RUBRIPES (JAPANESE PUFFERFISH) (TAKIFUGU RUBRIPES).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; PISCES; GNATHOSTOMATA;
OC   OSTEICHTHYES; ACTINOPTERYGII; TETRAODONTIFORMES.
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 96202283.
RA   TROWER M.K., ORTON S.M., PURVIS I.J., SANSEAU P., RILEY J.,
RA   CHRISTODOULOU C., BURT D., SEE C.G., ELGAR G., SHERRINGTON R.,
RA   ROGAEV E.I., ST GEORGE-HYSLOP P.H., BRENNER S., DYKES C.W.;
RL   PROC. NATL. ACAD. SCI. U.S.A. 93:1366-1369(1996).
CC   -!- FUNCTION: CATALYZES THE EXCHANGE OF EUKARYOTIC INITIATION FACTOR
CC       2-BOUND GDP FOR GTP (BY SIMILARITY).
CC   -!- SUBUNIT: COMPLEX OF FIVE DIFFERENT SUBUNITS; ALPHA, BETA, GAMMA,
CC       DELTA AND EPSILON (BY SIMILARITY).
CC   -!- SIMILARITY: BELONGS TO THE EIF-2B ALPHA/BETA/DELTA SUBUNITS
CC       FAMILY.
CC   --------------------------------------------------------------------------
CC   This SWISS-PROT entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use  by  non-profit  institutions as long  as its content  is  in  no  way
CC   modified and this statement is not removed.  Usage  by  and for commercial
CC   entities requires a license agreement (See http://www.isb-sib.ch/announce/
CC   or send an email to license@isb-sib.ch).
CC   --------------------------------------------------------------------------
DR   EMBL; U40756; G1117954; -.
KW   INITIATION FACTOR; PROTEIN BIOSYNTHESIS.
SQ   SEQUENCE   355 AA;  39129 MW;  A1B2DE8A CRC32;
     MPGADKEVDL TERIEAFLSD LKRGGSGTGP LRGSSETARE TTALLRRITA QARWSSAGDL
     MEIIRKEGRR LIAAQPSETT VGNMIRRVLK IIREEYARSR GSSEEADQQE SLHKLLTSGG
     LSEENFRQHF AALRANVIEA INELLTELEG TTDNIAMQAL EHIHSNEVIM TVGRSRTVEA
     FLKDAARKRK FHVIVAECAP FCQGHKMATS LSTAGIETTV IADAAIFAVM SRVNKVIIGT
     QTVLANGGLR AVNGTHTLAL AAKHHSTPLI VCAPMFKLSP QFPNEEDTFH KFVSPHEVLP
     FTEGEILSKV NVHCPVFDYV PPELITLFIS NIGGHAPSYI YRLMSELYHP EDHEL
//
